Bubble Up Biscuit Pizza Casserole (Easy Weeknight Dinner) – Cheesy, Cozy, and Crowd-Pleasing

Bubble up biscuit pizza casserole is the ultimate answer to busy weeknight dinners when time is short but comfort food cravings are strong. This easy pizza casserole combines refrigerated biscuit dough, classic pizza flavors, and gooey melted cheese into one simple, family-friendly dish that’s ready with minimal prep and maximum payoff.

The name “bubble up” comes from the way biscuit pieces expand and puff up while baking, creating a soft, fluffy interior with golden edges. When paired with pizza sauce, cheese, and toppings, those biscuit pieces soak up flavor and turn into a hearty, satisfying base that feels like a cross between deep-dish pizza and a cheesy bake.

What makes this bubble up biscuit pizza casserole especially popular is how customizable it is. You can keep it classic with pepperoni and mozzarella, or turn it into a fully loaded pizza bake with sausage, vegetables, olives, and extra cheese. It’s also a great way to use up leftover pizza toppings from the fridge.

This dish is ideal for families, picky eaters, casual gatherings, and meal planning. It requires no dough-making, no rising time, and no complicated techniques—just simple ingredients and one baking dish.

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Why Bubble Up Biscuit Pizza Casserole Works So Well

This casserole works because it uses refrigerated biscuits as a shortcut dough. As they bake, the biscuit pieces absorb sauce and cheese while still staying tender and fluffy. Unlike traditional pizza crusts, there’s no rolling, stretching, or shaping involved.

Another reason this recipe is so successful is balance. The biscuits provide structure, the sauce adds moisture and tang, and the cheese creates richness. Everything bakes together into cohesive, scoopable servings that hold their shape without drying out.

It’s also a forgiving recipe. Exact measurements aren’t critical, making it perfect for beginner cooks and stress-free weeknight cooking.

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Ingredients

• 2 cans refrigerated biscuit dough, cut into quarters
• 1½ cups pizza sauce
• 2 cups shredded mozzarella cheese
• 1 cup sliced pepperoni
• 1 teaspoon Italian seasoning
• ½ teaspoon garlic powder
• Optional toppings: cooked sausage, bell peppers, mushrooms, olives

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Instructions

1. Preheat oven to 375°F (190°C). Grease a 9×13-inch baking dish.
2. Cut biscuit dough into quarters and place in a large mixing bowl.
3. Add pizza sauce, Italian seasoning, and garlic powder. Toss until biscuits are evenly coated.
4. Fold in half of the shredded mozzarella cheese and half of the pepperoni.
5. Transfer mixture to the prepared baking dish and spread evenly.
6. Top with remaining mozzarella cheese and pepperoni.
7. Bake uncovered for 35–40 minutes, or until biscuits are cooked through and top is golden and bubbly.
8. Let casserole rest for 5 minutes before serving.

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Tips for the Best Biscuit Pizza Bake

Cut Biscuits Evenly:
Uniform pieces ensure even baking throughout the casserole.

Don’t Overcrowd Toppings:
Too many toppings can weigh down the biscuits and prevent proper rising.

Check the Center:
Insert a knife into the middle to confirm biscuits are fully cooked.

Rest Before Serving:
Letting the casserole sit briefly helps it set and makes serving easier.

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Variations and Customizations

Meat Lover’s Pizza Casserole:
Add cooked sausage and bacon along with pepperoni.

Veggie Pizza Bake:
Use bell peppers, mushrooms, onions, and olives for a meatless version.

Supreme Pizza Casserole:
Combine meats and vegetables for a fully loaded option.

Cheese Lover’s Version:
Add provolone or cheddar along with mozzarella.

Spicy Pizza Bake:
Use spicy pepperoni and add red pepper flakes.

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Serving Suggestions

Bubble up biscuit pizza casserole pairs well with simple sides that balance its richness:

• Fresh green salad with vinaigrette
• Steamed vegetables
• Garlic bread or breadsticks
• Simple fruit salad

It’s also hearty enough to serve on its own as a complete meal.

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Storage and Reheating

Refrigerator:
Store leftovers in an airtight container for up to 4 days.

Reheating:
Reheat in the oven or microwave until warmed through.

Freezing:
Freeze baked casserole portions for up to 2 months. Thaw before reheating.

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Why This Is a Perfect Weeknight Dinner

This bubble up biscuit pizza casserole checks every box for weeknight cooking: fast prep, minimal cleanup, customizable ingredients, and flavors everyone recognizes and loves. It’s a reliable option when you need dinner on the table without stress.